A real-time model of the cerebellar circuitry underlying classical conditioning: A combined simulation and robotics study

نویسندگان

  • Paul F. M. J. Verschure
  • Matti Mintz
چکیده

Although key components of the cerebellar circuitry relevant to classical conditioning have been identi"ed, the question how they act together is still unresolved. In this simulation study, we investigate a real-time model which captures basic anatomical and physiological properties of this system. We show that this model displays realistic learning performance over a range of inter-stimulus intervals, and demonstrate its stability using a mobile robot solving an obstacle avoidance task. 2001 Elsevier Science B.V. All rights reserved.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The cerebellum in action: a simulation and robotics study.

The control or prediction of the precise timing of events are central aspects of the many tasks assigned to the cerebellum. Despite much detailed knowledge of its physiology and anatomy, it remains unclear how the cerebellar circuitry can achieve such an adaptive timing function. We present a computational model pursuing this question for one extensively studied type of cerebellar-mediated lear...

متن کامل

The neural circuitry and molecular mechanisms underlying delay and trace eyeblink conditioning in mice.

Classical eyeblink conditioning (EBC), a simple form of associative learning, has long been served as a model for motor learning and modulation. The neural circuitry of EBC has been studied in detail in rabbits. However, its underlying molecular mechanisms remain unclear. The advent of mouse transgenics has generated new perspectives on the studies of the neural substrates and molecular mechani...

متن کامل

Eyeblink Conditioning in Schizophrenia: A Critical Review

There is accruing evidence of cerebellar abnormalities in schizophrenia. The theory of cognitive dysmetria considers cerebellar dysfunction a key component of schizophrenia. Delay eyeblink conditioning (EBC), a cerebellar-dependent translational probe, is a behavioral index of cerebellar integrity. The circuitry underlying EBC has been well characterized by non-human animal research, revealing ...

متن کامل

Cerebellar functional abnormalities in schizophrenia are suggested by classical eyeblink conditioning.

BACKGROUND Previous research suggests that schizophrenia may result from disruptions in a cortico-cerebellar-thalamic-cortical circuit (CCTCC) producing a mental incoordination or "cognitive dysmetria." To further evaluate the cerebellar contribution to this disrupted circuitry, medication-free patients with schizophrenia completed classical eyeblink conditioning, a cerebellar-mediated learning...

متن کامل

The Cerebellum Chip: an Analog VLSI Implementation of a Cerebellar Model of Classical Conditioning

We present a biophysically constrained cerebellar model of classical conditioning, implemented using a neuromorphic analog VLSI (aVLSI) chip. Like its biological counterpart, our cerebellar model is able to control adaptive behavior by predicting the precise timing of events. Here we describe the functionality of the chip and present its learning performance, as evaluated in simulated condition...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Neurocomputing

دوره 38-40  شماره 

صفحات  -

تاریخ انتشار 2001